The 2010 South Carolina Gamecocks baseball team represented the University of South Carolina in the 2010 NCAA Division I baseball season. The Gamecocks played their home games in Carolina Stadium. The team was coached by Ray Tanner, who was in his fourteenth season at Carolina.
USC finished second in the Southeastern Conference regular season standings, and received an at-large bid to the 2010 NCAA Division I Baseball Tournament. The Gamecocks were designated the #1 seed and host of the Columbia Regional. Carolina went 3–0 in their Regional to advance to the Super Regionals. The Gamecocks beat Coastal Carolina in two games to win the Myrtle Beach Super Regional and advance to the 2010 College World Series. After losing the opener, the Gamecocks won their next six games to win the national championship, defeating UCLA in the CWS Championship Series in consecutive games, 7–1 and 2–1.